Triamcinolone Acetonide 21-acetate Glucocorticoid Steroids Corticosteroid Triamcinolone Acetonide Acetate

The glucocorticoid triamcinolone acetonide is clinically used for the treatment of suppression of inflammation in chronic inflammatory diseases such as asthma, rheumatiod arthritis, inflammatory bowel disease and autoimmune diseases (Barnes, 1998; Buttgereit, 2000; Uckermann et al., 2005). Triamcinolone acetonide acetate is another derivatives of triamcinolone, which has been used in therapy for several decades. Despite its great importance, no crystal structures of the title compound has been reported. But crystal structure of it's analogue compounds, triamcinolone diacetate chloroform solvate and triamcinole acetonide methanol solvate have been reported (Suitchlmezian et al., 2006 & Jess et al., 2006). In the title compound, the bond lengths and angles are in agreement with those reported for other triamcinolone derivatives (Suitchlmezian et al., 2006; Jess et al., 2006). and are within the expected ranges. The molecular framework consists of five condensed rings, including three six-membered rings and two five-membered rings

3. Applications:

Triamcinolone acetonide is a synthetic corticosteroid used to treat various skin conditions, to relieve the discomfort of mouth sores, and in nasal spray form, to treat allergic rhinitis. It is a more potent derivative of triamcinolone, and is about eight times as potent as prednisone.
It is also known under the brand names Kenalog (topical) and Volon A as an injection, to treat allergies, arthritis, eye diseases, intestinal problems, and skin diseases. In 2014, the FDA made triamcinolone acetonide an over-the-counter drug in the USA in nasal spray form under the brand name Nasacort.

Triamcinolone acetonide as an intra-articular injectable has been used to treat a variety of musculoskeletal conditions. When applied as a topical ointment, it is used for blistering from poison ivy, oak, and sumac, applied to the skin, avoiding eyes, mouth, and genital area. It provides relatively immediate relief and is used before using oral prednisone. Oral and dental paste preparations are used for treating aphthous ulcers.
As an intravitreal injection, triamcinolone acetonide has been used to treat various eye diseases and has been found useful in reducing macular edema. Drug trials have found it to be as efficient as anti-VEGF drugs in eyes with artificial lenses over a two-year period.
Uncommonly, intramuscular injection of triamcinolone acetonide may be indicated for the control of severe or incapacitating allergic states for which conventional treatments have failed, such as asthma, atopic dermatitis, contact dermatitis, perennial or seasonal allergic rhinitis, serum sickness, and transfusion and drug hypersensitivity reactions.

Triamcinolone acetonide is also used in veterinary medicine as an ingredient in topical ointments and in topical sprays for control of pruritus in dogs. A series of injections with triamcinolone acetonide or another corticosteroid may reduce keloid size and irritation. It is also used as a preinductor and/or inductor of birth in cows.
Many drugs have been demonstrated to increase triamcinolone acetonide concentration in the blood to well above the intended level. Patients should inform doctors about any other drugs they are taking.Triamcinolone acetonide should not be used by those with tuberculosis or untreated fungal, bacterial, systemic viral or herpes simplex infections without consulting a doctor first.

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