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Spironolactone CAS 52-01-7 Prohormone Steroids Pharmaceutical Intermediate Powder

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Spironolactone CAS 52-01-7 Prohormone Steroids Pharmaceutical Intermediate Powder

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Large Image :  Spironolactone CAS 52-01-7 Prohormone Steroids Pharmaceutical Intermediate Powder

Product Details:
Place of Origin: China
Brand Name: YT
Certification: ISO9001
Model Number: 52-01-7
Payment & Shipping Terms:
Minimum Order Quantity: 10 grams
Price: Negotiable
Packaging Details: very discreet package
Delivery Time: within 24 hours
Payment Terms: T/T, L/C, Western Union, MoneyGram
Supply Ability: 500kg/Month
Detailed Product Description
Product Name: Spironolactone CAS: 52-01-7
Place Of Origin: China Molecular Formula: C24H32O4S
Molecular Weight: 416.5735 Appearance: White Crystalline Powder.
Whatsapp: +852 65651250
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Spironolactone CAS 52-01-7 Prohormone Steroids Pharmaceutical Intermediate Powder






Spironolactone CAS 52-01-7 Brand: Hyper
MW: 416.57 MSDS: Avaiable
MF : C24H32O4S Sample: Avaiable
Category:Urinary System Min order: 10grams
Quality standard :   USP35 Place of Origin:China
Introduction Spironolactone is a diuretic and is used as an antiandrogen.
Character White or almost white minor crystalline powder
Applications Pharmaceutical raw materials




1. Osmotic diuretics
2. treat hydropsy
3. anti-hypertension assistant
4. used for primary aldosteronism



Spironolactone CAS 52-01-7 Prohormone Steroids Pharmaceutical Intermediate Powder 0





Appearance (Ph.Eur.) A white or yellowish-white powder White powder
Solubility (Ph.Eur.) Practically insoluble in water, soluble in ethanol (96%) Complies
A. IR –spectrum (Ph.Eur.) Meet the requirement Complies
A. IR –spectrum (USP) Meet the requirement Complies
B. TLC (Ph.Eur.) Meet the requirement Complies
B. UV absorption (USP) Meet the requirement Complies
C. Colour reaction (Ph.Eur.) Meet the requirement Complies
C. Precipitate reaction (USP) Meet the requirement Complies
Specific optical rotation -41°~-46° -42.8°
(Ph.Eur.) -41°~-45° -42.9°
Sulphated ash (Ph.Eur.) ≤0.1% 0.00%
Related substances (Ph.Eur.)
Impurity A ≤0.2% N.D.
Impurity B ≤0.3% N.D.
Impurity C ≤0.2% N.D.
Impurity D ≤0.15% N.D.
Impurity E ≤0.3% N.D.
Impurity I ≤0.5% 0.05%
Any unspecified impurity ≤0.10% Complies
Total ≤0.7% 0.13%
Ordinary impurities (USP) ≤2.0% Complies
Free thiol compounds (Ph.Eur.) ≤0.05mL Complies
Free mercapto compounds (USP) ≤0.10mL Complies
Chromium (Ph.Eur.) ≤50ppm Complies
Assay 97.5%~102.0% 100.90%
HPLC (Ph.Eur.) 97.5%~103.0% 99.60%
HPLC (USP)    
Residual solvent (In-house) ≤3000ppm 90ppm
Methanol ≤720ppm ≤LOD (0.0046ppm)
Tetrahydrofuran ≤880ppm ≤LOD (0.23ppm)
Particle size (In-house) 95% ≤ 20 microns Complies
Conclusion Compiles with EP7/USP35


General introduction:It is a synthetic 17-lactone drug that is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat heart failure, ascites in patients with liver disease, low-renin hypertension, hypokalemia, secondary hyperaldosteronism (such as occurs with hepatic cirrhosis), and Conn's syndrome (primary hyperaldosteronism). On its own, spironolactone is only a weak diuretic because its effects target the distal nephron (collecting tubule), where urine volume can only be slightly modified; but it can be combined with other diuretics to increase efficacy. About one person in one hundred with hypertension has elevated levels of aldosterone; in these persons, the antihypertensive effect of spironolactone may exceed that of complex combined regimens of other antihypertensives. Due to its antiandrogen effect, it can also be used to treat hirsutism. It is also used for treating hair loss and acne in women, and can be used as a topical medication for treatment of male baldness. It is commonly used to treat symptoms of polycystic ovary syndrome (PCOS) such as excess facial hair and acne. It can also cause gynecomastia in males and should never be given with potassium supplementation for fear of the development of hyperkalemia.



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