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|Manufacturer:||GC||Product Name:||Amiloride Hydrochloride; Amiloride HCl;amiloride Hydrochloride Hydrate;2016-88-8;Diuretic Powder;Diuretic;Pharmaceutical Raw Materials,Treat High Blood Pressure|
1. Quick Detail:
Pharmaceutical Raw Materials Diuretic Drug CAS 2016-88-8 Amiloride Hydrochloride Amiloride HCL
2. Basic Informations:
English name: amiloride hydrochloride hydrate
Alias: Amiloride Hydrochloride; Amiloride HCl; (3,5-diamino-6-chloropyrazin-2-yl) -N- (diaminomethylidene) oxomethanaminium
EINECS Number: 217-958-2
Melting point: 293-294 ℃
Boiling point: 628.1 ° C at 760 mmHg
Flash Point: 333.7 ° C
Water-soluble: <0.1 g / 100 mL at 19.5 ℃
Vapor Pressure: 1.08E-15mmHg at 25 ° C
Uses:Used as a weak diuretic drug
Appearance: White or almost white fine crystalline powder
Amiloride is a potassium-sparing diuretic, first approved for use in 1967 (then known as MK 870), used in the management of hypertension and congestive heart failure. Amiloride was also tested as treatment of cystic fibrosis, but it was revealed inefficient in vivo due to its short time of action, therefore longer-acting epithelial sodium channel(ENaC) inhibitors may prove more effective, e.g. benzamil.
Amiloride works by directly blocking the epithelial sodium channel (ENaC) thereby inhibiting sodium reabsorption in the late distal convoluted tubules, connecting tubules, and collecting ducts in the kidneys (this mechanism is the same fortriamterene). This promotes the loss of sodium and water from the body, but without depleting potassium. The drug is often used in conjunction with thiazide (e.g. co-amilozide) or loop diuretics (e.g. co-amilofruse). Due to its potassium-sparing capacities, hyperkalemia (high blood potassium levels) is occasionally observed in patients taking amiloride. The risk is high in concurrent use of ACE inhibitors or spironolactone. Patients are also advised not to use potassium-containing salt replacements. Amiloride also carries the risk of developing an acidosis.
A fraction of the effects of amiloride is inhibition of cyclic GMP-gated cation channels in the inner medullary collecting duct.
Amiloride has a second action on the heart, blocking Na+/H+ exchangers sodium–hydrogen antiporter 1 or NHE-1. This minimizes reperfusion injury in ischemic attacks.
Amiloride also blocks the Na+/H+ antiporter on the apical surface of the proximal tubule cells, in the kidney, abolishing more than 80% of the action of angiotensin II on the secretion of hydrogen ions in proximal tubule cells.
Acid-sensing ion channels (ASICs) are also sensitive to inhibition by amiloride. ASICs are involved in nociceptorresponses to pH.
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5. Our Competitive Advantage:
Professional Manufacture: HONGKONG YUANCHENG GONGCHUANG TECHNOLOGY CO., LIMITED
is a legit and professional pharmaceutical manufacturer specialized in steroid hormone powders, steroid
injectable liquids, peptides,pharmaceutical raw materials & its intermediate.Our factory is in Nanhu Shouyi
Industrial District, just by the side of the beautiful South Lake in Wuhan. Our company integrates R&D,
producing, operating and marketing into an organic whole. All products are produced under
GMP conditions according to Standard Operation Procedure(SOP),not from little underground labs or black markets, so the quality is guaranteed. We have authority of export and import, and have experience of export for more than 10 years.
Minimum Order: 10-100 grams.our min packing of each powder is 10g or 100g, but some expensive powder can be bought at several grams.
Payment Method: Western Union,Money Gram,T/T.
Professional Delivery: By courier ( EMS, DHL, Fedex, UPS,TNT) is prefered, bulk order can be negotiated.5-7 business days delivery in timely manner. Tracking No. is available ,we can provide you latest tracking of our customers to check validity of delivery if you need.
Discreetly Packing: Safe and professional disguised package can be guaranteed.
Plenty In Stock: Most of powders are in stock.We export over 1000 kilograms of steroid powder per month.
High Delivery Rate: Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%, As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.
Contact Person: sinopeptides