Female Progesterone Hormones Antiprogestogens Mifepristone Mifepriston Dianhydride

1.  Quick Detail:
 
English name: mifepristone
English Name: Mifepriston Dianhydride; (11R, 13S, 17S) -11- (4-dimethylaminophenyl) -17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11, 12,14,15,16-decahydrocyclopenta [a] phenanthren-3-one
CAS: 84371-65-3
Formula: C29H35NO2
MW: 429.5937
Molecular Structure:
 

Density: 1.18g / cm3
Boiling point: 628.6 ° C at 760 mmHg
Flash Point: 334 ° C
Vapor Pressure: 1.14E-16mmHg at 25 ° C
Uses:As anti-pregnancy drugs
Assay:99%
Appearance:White powder
 
2.  Description:
 
Mifepristone (or RU-486) is a synthetic steroid compound with both antiprogesterone and antiglucocorticoid properties. The compound is a 19-nor steroid with substitutions at positions C11 and C17 (17 beta-hydroxy-11 beta-[4-dimethylamino phenyl] 17 alpha-[1-propynyl]estra-4,9-dien-3-one), which antagonizes cortisol action competitively at the receptor level.
 
Mifepristone is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. It is also a powerful glucocorticoid receptor antagonist, and has occasionally been used in refractory Cushing's syndrome (due to ectopic/neoplastic ACTH/cortisol secretion). During early trials, it was known as RU-38486 or simply RU-486, its designation at the Roussel Uclaf company, which designed the drug. The drug was initially made available in France, and other countries then followed—often amid controversy. It is marketed under tradenames Korlym and Mifeprex, according to FDA Orange Book.
 
Mifepristone was the first antiprogestin to be developed and it has been evaluated extensively for its use as an abortifacient. The original target for the research group, however, was the discovery and development of compounds with antiglucocorticoid properties. These antiglucocorticoid properties are of great interest in the treatment of severe mood disorders and psychosis, although a review of published articles was inconclusive on their efficacy, and considered the use of these drugs in mood disorders at 'proof of concept' stage. It is on the World Health Organization's List of Essential Medicines.
 

 
Mifepristone is used alone or in combination with misoprostol (Cytotec) to end an early pregnancy. Early pregnancy means it has been 49 days or less since your last menstrual period began. Mifepristone is in a class of medications called antiprogestational steroids. It works by blocking the activity of progesterone, a substance your body makes to help continue pregnancy.
 
Mifepristone is also available as another product (Korlym), which is used to control hyperglycemia (high blood sugar) in people with a certain type of Cushing's Syndrome in which the body makes too much of the hormone cortisol. This monograph only gives information about mifepristone (Mifeprex), which is used alone or in combination with another medication to end an early pregnancy. If you are using mifepristone to control hyperglycemia caused by Cushing's syndrome, read the monograph entitled mifepristone (Korlym) that has been written about this product.
 
4.  Specifications:
 
COA:
 
 

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