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| Purity: | 99% | Appearance: | White Powder |
|---|---|---|---|
| Usage: | For Weight Loss | CAS No.: | 125-69-9 |
| Quality: | USP Grade Product | ||
| High Light: | fat burning steroids,fat loss steroids |
||
DXM Dextromethorphan Hydrobromide Weight Loss Steroids Pharma Grade Medicine 99 %
Tag:Dextromethorphan HydrobromideWeight Loss Powders;Dextromethorphan Maleate HBR;
Antitussive Drug
Basic Description:
|
Product Name |
Dextromethorphan Hydrobromide |
|
Synonyms |
Dextromethorphan maleate HBR; dextromethorphan HBR; (9alpha,13alpha,14alpha)-3-methoxy-17-methylmorphinan hydrobromide; 3-methoxy-17-methylmorphinan hydrobromide; (9alpha,13alpha,14alpha)-3-methoxy-17-methylmorphinan hydrobromide hydrate; Destromethorphan hydrobromide |
|
Molecular Formula |
C18H28BrNO2 |
|
Molecular Weight |
370.3244 |
|
InChI |
InChI=1/C18H25NO.BrH.H2O/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H;1H2/t15-,17+,18+;;/m1../s1 |
|
CAS Registry Number |
125-69-9 |
|
EINECS |
204-750-1 |
|
Molecular Structure |
|
|
Boiling point |
486.1°C at 760 mmHg |
|
Flash point |
247.8°C |
|
Vapour Pressure |
2.92E-10mmHg at 25°C |
|
Assay |
99% |
|
Appearance |
White or white crystalline powder |
Description:
Dextromethorphan (DXM or DM) is an antitussive (cough suppressant) drug. It is one of the active
ingredients in many over-the-counter cold and cough medicines,
including generic labels and store brands, Benylin DM, Mucinex DM, Robitussin, NyQuil, Dimetapp,
Vicks, Coricidin, Delsym, TheraFlu, and others. Dextromethorphan has also found other uses in
medicine, ranging from pain relief to psychological applications. It is sold in syrup, tablet, spray, and
lozenge forms. In its pure form, dextromethorphan occurs as a white powder.
DXM is also used recreationally. When exceeding label-specified maximum dosages,
dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects,
including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist.
DXM and its major metabolite, dextrorphan, also acts as an NMDA receptor antagonist at high doses,
which produces effects similar to, yet distinct from, the dissociative states created by other dissociative
anaesthetics such as ketamine and phencyclidine. As well, the metabolite 3-methoxymorphinan
of dextrorphan (thus a second-level metabolite of DXM) produces local anesthetic effects
in rats with potency above dextrorphan, but below that of DXM.
Medical use
Generic Dextromethorphan syrup.
The primary use of dextromethorphan is as a cough suppressant, for the temporary relief of cough
caused by minor throat and bronchial irritation (such as commonly accompanies the flu and common
cold), as well as those resulting from inhaled particle irritants.
A 2004 study showed that dextromethorphan was no more effective for children than a placebo.Studies
conducted by the American Academy of Pediatrics show that dextromethorphan is not superior to a
placebo in providing nocturnal symptom relief for children with cough and sleep difficulty due to upper
respiratory infections.
A combination of dextromethorphan and quinidine, a CYP2D6 inhibitor, has been shown to alleviate
symptoms of easy laughing and crying (pseudobulbar affect) in patients with amyotrophic lateral
sclerosis and multiple sclerosis.Dextromethorphan is also being investigated as a possible treatment for
neuropathic pain and pain associated with fibromyalgia.In 2010, the FDA approved the combination
product dextromethorphan/quinidine (Nuedexta) for the treatment of pseudobulbar affect (PBA).
Dextromethorphan has been shown to be effective in treating opioid withdrawal. At doses of 2 mg/kg in
rats all signs of opioid withdrawal were eliminated.
COA:
|
TEST |
SPECIFICATION |
TEST RESULT |
|
|
Apperance |
Practically white crystal or crystalline powder |
White crystalline powder |
|
|
Identification |
A. FT-IR |
The sample spectrum correspond to that of the reference standard |
Conforms |
|
B. UV |
Not more than 3.0% difference of RS(on anhydrous basis) |
1.4% |
|
|
C. Bromide Test |
Yellow white precipitate formed |
Conforms |
|
|
Specific rotation A |
1.8w/v in water:Not more than 1.0% difference of RS At 325nm and 25℃(on anhydrous basis) |
0.23% |
|
|
Specific rotation B |
2.0%w/v in 0.1M HCL: +28℃to +30℃ at 589nm and 20℃(on anhydrous basis) |
+28.2℃ |
|
|
Clarity of solution |
5.0%w/v in alcohol:Clear and colorless |
Conforms |
|
|
PH |
5.2-6.5(1 in 100 water solution) |
6.1 |
|
|
Acidity or Alkalinity |
Not more than 0.4ml of 0.01M HCLconsumed |
0.24ml |
|
|
Water(by KF Titration) |
4.0%—5.5% |
5.0% |
|
|
Relates substances (by HPLC;ph；Eur) |
a)For each of impurities A,B,C,D not more than 0.5% |
Impurities A,B,C,D; Not detected.
|
|
|
b)Among impurities A,B,C,D not more than one greater than 0.25% |
0 |
||
|
C)For each of unspecified impurities, not more than0.10% |
﹤0.05% |
||
|
d)Total impurities not more than 1.0% |
﹤0.05% |
||
|
Residue on Ignition |
Not more than 1.0% |
0.05% |
|
|
N,N-Dimethylaniline |
Not more than 0.001% |
Conforms |
|
|
Phenolic compounds |
No blue-green color develops |
Conforms |
|
|
Assay A (by HPLC) |
98.0%~102.0%(on anhydrous basis) |
100.0% |
|
|
Assay B(by titration) |
99.0%~101.0%(on anhydrous basis) |
100.4% |
|
|
Residual solvents |
Methanol≤3000ppm
Toluene≤890ppm
Acetone≤5000ppm |
52ppm
0.8ppm
2ppm |
|
|
Storage |
Preserve in tight containers；protected from light |
Conforms |
|
|
Compliance Statement |
USP35/EP7 |
||
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