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|Product Name:||Cardarine||Other Name::||Oral Coluracetam;Coluracetam, MKC-231;135463-81-9|
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Pharmaceutical Raw Materials Nootropic Agent Oral SARM Coluracetam (BCI-540 / MKC-231) CAS 135463-81-9
Coluracetam (code name BCI-540; formerly MKC-231) is a nootropic agent of the racetam family.It was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depressive disorder (MDD), which was preceded by being awarded a "Qualifying Therapeutic Discovery Program Grant" by the state of California. Findings from phase IIa clinical trials have suggested that it would be a potential medication for comorbid MDD with generalized anxiety disorder (GAD). BrainCells Inc is currently out-licensing the drug for this purpose. It may also have potential use in prevention and treatment of ischemicretinopathy and retinal and optic nerve injury.
Coluracetam has been shown to reverse the loss of choline acetyltransferase production in the medial septal nucleus of rats exposed to phencyclidine (PCP), and is considered a potential therapeutic drug for schizophrenia.
Coluracetam a nootropic agent composed of a Racetam compound synthetically derived from Piracetam. It is also soluble ethanol. It was first developed and tested in Japan by Mitsubishi Tanabe Pharma Corporation for Alzheimer’s disease in 2005. It was then made available to the general public in 2013 and quickly gained recognition for its cognitive effects.
When in action, Coluracetam improves the body’s choline uptake through the high affinity choline uptake (HACU) process; the mechanism for absorbing and converting choline into neurons during the Acetylcholine synthesis process. By facilitating the conversion of large amounts of choline into Acetylcholine, the brain memory, alertness and attention is improved. Coluracetam also affects sections of the brain that are concerned with visual processing, and is therefore touted to improve the sense of sight.
According to BrainCells Inc, Coluracetam is a potential treatment for various diseases and disorders that affect the brain and nervous system. Such diseases and disorders that Coluracetam has the potential of treating and preventing include; ischemic retinopathy and optic nerve injuries. The ability of Coluracetam to reverse the loss of choline production makes it a potential drug for treatment of schizophrenia. These refer to the clinical benefits of Coluracetam.
Coluracetam also has various other benefits that are not clinical. It is helpful in enhancing cognition, improving the memory and better decision making; it does this by increasing choline uptake and synthesis of Acetylcholine. It is also able to reduce cytotoxicity (a state of being toxic to body cells) of the brain, which is usually caused by an influx of calcium in cultured cortical neurons. This occurs when supply of oxygen to the brain is limited. Coluracetam is also an anti-depressant and can therefore be used in treating various forms of depression. It can be effectively used to deal with stress and hangovers by creating feelings of contentment and peace. This is a motivation boosting nootropic, a distinct feature from the other nootropics. Another unique benefit of Coluracetam is that it is beneficial for eyesight. It improves visual recognition and color vision. Coluracetam has also been found to be effective in the treatment of patients experiencing major depressive disorder and general anxiety disorder making this nootropic supplement an effective anti-depressant.
A unique feature of Coluracetam as a nootropic that makes it distinct is that it is the only high affinity choline uptake (HACU) enhancer. This enables it to speed up the flow of Acetylcholine in the brain thereby improving the brain functions of memory, mood, intelligence and learning.
The dosage for Coluracetam may not have a medically recommended standard, but a maximum of 200 mg a day is advisable. The dosage also varies depending on the reason for using the supplement. For instance, users taking the supplement to treat major depressive disorder or general anxiety disorder are advised to take 300 mg a day in order to get the maximum benefits.
The use of Coluracetam is relatively safe with very few side effects. The common side effect that may be experienced is headaches. This can however be countered by stacking Coluracetam with Centrophenoxine, Alpha GPC, or CDP Choline to reduce such side effects.
COA of Coluracetam:
|Description||White crystalline powder, odorless||Conform|
|Solubility||Easily soluble in water, unsoluble in ethanol||Conform|
|Solution clarity and color||Solution should be clear and colorless||Conform|
|Related substances||5'CMP 0.3%
Total other impurity
|Loss on drying||≤6.0%||1.3%|
|Assay (on dried basis)||≥99.0%||99.8%
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|Product name||CAS No.|
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