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|Manufacturer:||GC||Product Name:||Cisatracurium Besylate;Cisatracurium Besylate;96946-42-8;Cisatracurium Besilete;96946-42-8;Pharmaceutical Raw Materials;Pharmaceutical|
1. Quick Detail:
Pharmaceutical Raw Materials Skeletal Muscle Relaxant CAS 96946-42-8 Cisatracurium Besylate
English name: Cisatracurium besilate
Alias: Cisatracurium besylate; Cisatracurium Besilete
Appearance: white to pale yellow powder
Assay: 99% min
Cisatracurium (formerly recognized as 51W89,and marketed as Nimbex) is a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively inanesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery ormechanical ventilation. It is a bisbenzyltetrahydroisoquinolinium agent with an intermediate duration of action. Cisatracurium is one of the ten isomers of the parent molecule, atracurium. Moreover, cisatracurium represents approximately 15% of the atracurium mixture.
As is evident with the parent molecule, atracurium,cisatracurium is also susceptible to degradation by Hofmann elimination and ester hydrolysis as components of the in vivo metabolic processes.See the atracurium page for information on Hofmann elimination in vivo versus the Hofmann degradation chemical reaction.
Because Hofmann elimination is a temperature- and plasma pH-dependent process, cisatracurium's rate of degradation in vivo is highly influenced by body pH and temperature just as it is with the parent molecule, atracurium: thus, an increase in body pH favors the elimination process,whereas a decrease in temperature slows down the process.
One of the metabolites of cistracurium via Hofmann elimination is laudanosine - see the atracurium page for further discussion of the issue regarding this metabolite. 80% of cisatracurium is metabolized eventually to laudanosine and 20% is metabolized hepatically or excreted renally. 10-15% of the dose is excreted unchanged in the urine.
Since Hofmann elimination is an organ-independent chemodegradative mechanism, there is little or no risk to the use of cisatracurium in patients with liver or renal disease when compared with other neuromuscular-blocking agents.
The two reverse ester linkages in the bridge between the two isoquinolinium groups make atracurium and cisatracurium poor targets for plasma cholinesterase, unlike mivacurium which has two conventional ester linkages.
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6. Our Competitive Advantage:
Professional Manufacture: HONGKONG YUANCHENG GONGCHUANG TECHNOLOGY CO., LIMITED
is a legit and professional pharmaceutical manufacturer specialized in steroid hormone powders, steroid
injectable liquids, peptides,pharmaceutical raw materials & its intermediate.Our factory is in Nanhu Shouyi
Industrial District, just by the side of the beautiful South Lake in Wuhan. Our company integrates R&D,
producing, operating and marketing into an organic whole. All products are produced under
GMP conditions according to Standard Operation Procedure(SOP),not from little underground labs or black markets, so the quality is guaranteed. We have authority of export and import, and have experience of export for more than 10 years.
Minimum Order: 10-100 grams.our min packing of each powder is 10g or 100g, but some expensive powder can be bought at several grams.
Payment Method: Western Union,Money Gram,T/T.
Professional Delivery: By courier ( EMS, DHL, Fedex, UPS,TNT) is prefered, bulk order can be negotiated.5-7 business days delivery in timely manner. Tracking No. is available ,we can provide you latest tracking of our customers to check validity of delivery if you need.
Discreetly Packing: Safe and professional disguised package can be guaranteed.
Plenty In Stock: Most of powders are in stock.We export over 1000 kilograms of steroid powder per month.
High Delivery Rate: Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%, As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.